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Tagamet (cimetidine) withdrawal and detection times for horses

Tagamet (cimetidine) is a h2 antagonist. Below: how 3 show and racing governing bodies list it, every published detection time for the dose and route studied, and the document and page each value comes from.HISA: Controlled medicationnamed in the rules of 22 state racing commissions

Published detection times for Tagamet

None of the detection-time lists we carry (FEI, HIWU, IFHA/EHSLC, Equestrian Canada, USEF) publishes a detection time for Tagamet. ShowSafe Pro answers "Unknown" for it, never "Clear", and quotes what each rulebook says about unlisted substances.

Advisory withdrawal guidance (RMTC)

The Racing Medication and Testing Consortium publishes withdrawal guidance built on HISA's detection times. It is advisory, not a rule, and ShowSafe Pro shows it beside the HISA result, never in place of it.

Dose and routeWithdrawal guidanceHISA detection timeSource
20 mg/kg orally twice daily for a total of 7 doses · oral24 h (1 day)24 h (1 day)RMTC advisory p. 3

How each rulebook lists Tagamet

Transcribed from the governing bodies' own documents. Each entry links to the document and quotes the row it came from.

Equestrian Canada

Permitted
  • Listed as: Permitted medication
“c. the anti-ulcer medications: cimetidine, ranitidine, sucralfate or omeprazole.” — source p. 6

HISA / HIWU

Controlled medication
  • Listed as: Controlled Medication Substance · Dose in the rule: 20 mg/kg orally twice daily for a total of 7 doses · Timing: not within 24 h (1 day) of competition · Screening limit: 400 ng/mL in serum or plasma · Routes: oral
“Cimetidine ... 20 mg/kg orally twice daily for a total of 7 doses ... RAT: 24 hours (9) ... 400 ng/mL in serum or plasma” — source p. 3
HISA Prohibited Substances List: Controlled Medications p. 7 · Last updated on December 8th, 2023
Controlled medication
  • Listed as: S7 Controlled Medication Substances · Dose in the rule: 20 mg/kg orally twice daily for a total of 7 doses · Timing: not within 24 h (1 day) of competition · Screening limit: 400 ng/mL in serum or plasma · Routes: oral
“Cimetidine ... Restricted administration time: 24 hours. 20 mg/kg orally twice daily for a total of 7 doses (9 horses) ... 400 ng/mL in serum or plasma” — source p. 7
HISA Prohibited List (Rule Series 4000), Anti-Doping and Medication Control Program p. 3 · Rule 4000 Series as published in the Federal Register 88 FR 5070 (Jan 26 2023, doc 2023-00957); FTC-approved Mar 27 2023; in force May 22 2023; current posted version on hisaus.org/regulations
Controlled medication
  • Listed as: S7 Controlled Medication - Rule 4212(b) 24-hour exception · Timing: not within 24 h (1 day) of competition
“(b) The following may be administered up to 24 hours prior to Post-Time: ... (3) anti-ulcer medications (e.g., Cimetidine, Omeprazole, and Ranitidine);” — source p. 3

ARCI

Controlled medication
  • Listed as: Class 5, Penalty D
“Cimetidine Tagamet 5 D” — source p. 20
ARCI Controlled Therapeutic Medication Schedule for Horses p. 2 · Version 4.2.1 (Revised December 2020); policies from Model Rules Version 15 (August 2026)
Permitted up to a threshold
  • Listed as: Controlled Therapeutic Medication · Dose in the rule: 20 milligrams per kilogram twice daily for 7 doses · Screening limit: 400 nanograms per milliliter of plasma or serum
“Cimetidine | 400 nanograms per milliliter of plasma or serum | 24 hours” — source p. 2

State racing commissions

Tagamet is named in the medication rules, threshold schedules or withdrawal guidance of 22 state racing commissions: Arizona, California, Colorado, Idaho, Illinois, Indiana, Kentucky, Louisiana, Maine, Maryland, Minnesota, Nebraska, New Jersey, New York, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Texas, Washington, West Virginia. Most states publish thresholds (concentrations), not times, and several adopt the ARCI schedule by reference. ShowSafe Pro Racing layers each state's rules over HISA or ARCI the way that state applies them, for all 32 states with live pari-mutuel racing.

Detection time is not withdrawal time

A published detection time tells you how long Tagamet stayed detectable in a handful of horses given one dose by one route. It does not tell you when your horse is clear: a bigger dose, a different route, repeated doses, a joint injection or a slower horse all push the real figure out, and every governing body says to add a safety margin set by your veterinarian. Here is how to read the rulebook.

ShowSafe Pro takes the doses already logged for your horse, matches each one to the published row for that dose and route, adds the margin your vet set, and flags anything the studies never covered as Unknown, ask your vet instead of guessing. Every answer shows the document, page and line it came from, for every rulebook the show runs under.

A detection time is the approximate period a drug or its metabolite stayed detectable in the horses studied, at the dose and route studied. It is not a withdrawal time. No governing body publishes withdrawal times for you; your veterinarian sets the safety margin for your horse. Nothing on this page is a veterinary ruling or a promise that a horse will test clean. Rules change; the document, version and page behind every value are linked so you can check the current text.

Questions about Tagamet

Does a published detection time mean my horse will test clean?

No. It is the approximate time Tagamet stayed detectable in the horses studied, at that dose and route. Your horse, dose, route and number of doses may differ. Every governing body tells you to add a safety margin set by your veterinarian, and none publishes a withdrawal time. ShowSafe Pro applies the published row for the dose and route you actually gave, adds your vet's margin, and says 'Unknown' when the studies do not cover what you gave.

Other h2 antagonist medications

Zantac (ranitidine)

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