Isoxsuprine withdrawal and detection times for horses

Isoxsuprine is a vasodilator. Below: how 7 show and racing governing bodies list it, every published detection time for the dose and route studied, and the document and page each value comes from.FEI: Controlled MedicationHISA: Banned / prohibitednamed in the rules of 7 state racing commissions

Published detection times for Isoxsuprine

None of the detection-time lists we carry (FEI, HIWU, IFHA/EHSLC, Equestrian Canada, USEF) publishes a detection time for Isoxsuprine. ShowSafe Pro answers "Unknown" for it, never "Clear", and quotes what each rulebook says about unlisted substances.

How each rulebook lists Isoxsuprine

Transcribed from the governing bodies' own documents. Each entry links to the document and quotes the row it came from.

FEI

2026 Equine Prohibited Substances List p. 21 · 2026 (effective 1 January 2026)
Controlled medication
  • Listed as: Controlled Medication
“CONTROLLED Isoxsuprine Vasodilator” — source p. 21

From 2027-01-01: 2027 Equine Prohibited Substances List p. 21 lists it as Controlled Medication.

Equestrian Canada

Controlled medication
  • Listed as: Prohibited substance
“Isoxsuprine” — source p. 11

AQHA

Restricted: dose and time limits
  • Listed as: Quantitatively Restricted Therapeutic Medication (VIO405) · Maximum dose: 1,600 milligrams per day for a 1,000 pound animal · Timing: not within 4 h of competition
“VIO405.10 Isoxsuprine - Guidelines: ... No part of a dose should be administered during the four hours prior to competing.” — source p. 47

APHA

Restricted: dose and time limits
  • Listed as: Permitted Therapeutic Substance (SC-085.A) · Maximum dose: 1,600 milligrams per day for a 1,000 pound animal · Timing: not within 4 h of competition
“11. Isoxsuprine. No part of a dose should be administered during the four (4) hours prior to competing.” — source p. 79

NCHA

2026 NCHA Rule Book - Standing Rule 35A, Medication and Drug Rules and Guidelines p. 12 · 2026 Rule Book, SR 35A extract (pages 75-95; PDF created 30 Jun 2026)
Restricted: dose and time limits
  • Listed as: Permitted Medication (35A.7) · Maximum dose: 1,600 milligrams per day for a 1,000-pound horse · Timing: not within 4 h of competition
“No part of a dose should be administered during the four hours prior to competing.” — source p. 12

HISA / HIWU

HISA Prohibited Substances List: Banned Substances p. 38 · Last updated on December 1st, 2023
Banned / prohibited
  • Listed as: S0 Non-Approved Substances
“Isoxsuprine ... Vasodilator” — source p. 38

ARCI

Controlled medication
  • Listed as: Class 4, Penalty C
“Isoxsuprine Vasodilan 4 C” — source p. 34

State racing commissions

Isoxsuprine is named in the medication rules, threshold schedules or withdrawal guidance of 7 state racing commissions: Colorado, Illinois, Kentucky, New Mexico, New York, Ohio, Washington. Most states publish thresholds (concentrations), not times, and several adopt the ARCI schedule by reference. ShowSafe Pro Racing layers each state's rules over HISA or ARCI the way that state applies them, for all 32 states with live pari-mutuel racing.

Detection time is not withdrawal time

A published detection time tells you how long Isoxsuprine stayed detectable in a handful of horses given one dose by one route. It does not tell you when your horse is clear: a bigger dose, a different route, repeated doses, a joint injection or a slower horse all push the real figure out, and every governing body says to add a safety margin set by your veterinarian. Here is how to read the rulebook.

ShowSafe Pro takes the doses already logged for your horse, matches each one to the published row for that dose and route, adds the margin your vet set, and flags anything the studies never covered as Unknown, ask your vet instead of guessing. Every answer shows the document, page and line it came from, for every rulebook the show runs under.

A detection time is the approximate period a drug or its metabolite stayed detectable in the horses studied, at the dose and route studied. It is not a withdrawal time. No governing body publishes withdrawal times for you; your veterinarian sets the safety margin for your horse. Nothing on this page is a veterinary ruling or a promise that a horse will test clean. Rules change; the document, version and page behind every value are linked so you can check the current text.

Questions about Isoxsuprine

What is the FEI detection time for Isoxsuprine?

On the 2026 FEI Equine Prohibited Substances List Isoxsuprine is a Controlled Medication. The FEI states that a detection time is not a withdrawal time; the treating veterinarian adds a safety margin.

Does a published detection time mean my horse will test clean?

No. It is the approximate time Isoxsuprine stayed detectable in the horses studied, at that dose and route. Your horse, dose, route and number of doses may differ. Every governing body tells you to add a safety margin set by your veterinarian, and none publishes a withdrawal time. ShowSafe Pro applies the published row for the dose and route you actually gave, adds your vet's margin, and says 'Unknown' when the studies do not cover what you gave.

All medications A to Z